Search widget Help
This widget is looking up genes in ensembl database 48 installed in our servers.
T. J. P. Hubbard, B. L. Aken, K. Beal1, B. Ballester1, M. Caccamo, Y. Chen, L. Clarke, G. Coates, F. Cunningham, T. Cutts, T. Down, S. C. Dyer, S. Fitzgerald, J. Fernandez-Banet, S. Graf, S. Haider, M. Hammond, J. Herrero, R. Holland, K. Howe, K. Howe, N. Johnson, A. Kahari, D. Keefe, F. Kokocinski, E. Kulesha, D. Lawson, I. Longden, C. Melsopp, K. Megy, P. Meidl, B. Overduin, A. Parker, A. Prlic, S. Rice, D. Rios, M. Schuster, I. Sealy, J. Severin, G. Slater, D. Smedley, G. Spudich, S. Trevanion, A. Vilella, J. Vogel, S. White, M. Wood, T. Cox, V. Curwen, R. Durbin, X. M. Fernandez-Suarez, P. Flicek, A. Kasprzyk, G. Proctor, S. Searle, J. Smith, A. Ureta-Vidal and E. Birney
Nucleic Acids Res. 2007 Vol. 35, Database issue:D610-D617.
A central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis. In 2004, Futreal et al. (Nat Rev Cancer.; 4(3):177-8) and Bamford et al. (Br J Cancer.; 91(2):355-8.) introduced a 'census' of cancer genes that indicates that somatic mutations in more than 1% of genes contribute to human cancer.
More recently, Sj÷blom et al. (see Science. 2006; 314(5797):268-74) reported the analysis of large-scale genetic variability data generate lists of Candidate Cancer Genes associated with different types of cancer (breast and colon carcinomas). In this work, the authors described Candidate Cancer Genes as those genes most likely to have been subjected to mutational selection during tumorogenesis. Candidate Cancer Genes list reported includes genes previously observed to be mutationally altered in human cancers, but also, genes in which no previous mutations in human cancers had been discovered but had been linked to cancer through functional studies and genes with no previous strong connection to neoplasia.
CARGO has been constructed in order to provide complete information regarding Candidate Cancer Genes (and other cancer-related genes) using user-friendly interface for control and visualization of information.
Searching for information related to cancer genes
CARGO has several recompiled cancer gene lists extracted from literature.
If you want to start looking up for any of them, just click on its tap and the list of genes will be display quickly.
Searching for information related to specific genes
Typically, researchers are interested in information related to a specific gene or protein. To launch a generic search simply click on the Search tab (see figure on the left) to display the search field, and type the gene symbol (e.g. TP53), or its "Ensembl id" (e.g. ENSG00000141510) in the search field. Then press the the search button or "Enter" to start the query.
The results list will be listed below the search field providing all those genes related to your query. Then, open the bioWidgets you like and get the information the widget provide.
You could also download the whole gene list from the "Export List" button.